School of Medicine - Clinical MedicineNeurology




Dr. Genjiro Hirose, now Professor Emeritus at Kanazawa Medical University, began working as a Senior Assistant Professor of Internal Medicine at Asanogawa General Hospital in October 1973. In 1974, he was promoted to the positions of Associate Professor and Head of the Department of Neurology at Kanazawa Medical University Hospital in Uchinada. In April 1986, he was named Professor and Chairman of the Department, and devoted himself to the training of young neurologists and pursuing research in the field of electrophysiology of the brain and nervous system for more than 31 years. Dr. Hirose retired in March 2005.
The second Professor and Chairman, Dr. Makoto Matsui, moved from the Department of Neurology, Utano National Hospital, to his present position in June 2005.
The areas of research interest are clinical neurology with a focus on the clinicopathological aspects of neurological disorders, as well as the pathogenesis and therapeutic strategies for neuroimmunological and neuro-infectious diseases.

Contact Information

TEL: 076-286-2211 +81-76-286-2211 / FAX: 076-286-3259 +81-76-286-3259 / Email:


Professor and Chair

  • MATSUI Makoto, M.D., Ph.D. 神内代表者JPG

Associate Professor

  • NAGAYAMA Shigemi, M.D., Ph.D.
  • SANADA Misturu, M.D., Ph.D.

Senior Assistant Professor

  • NAKANISHI Megumi, M.D., Ph.D.

Junior Assistant Professor

  • FUJITA-NAKATA Michiyo, M.D., Ph.D.

Assistant Professor

  • KAWAI Ukichiro,M.D.
  • UCHIDA Nobuaki,M.D.

Research Achievements

Research Activities

  • U.Kawai, N.Uchida, M.Oono, M.Fujita-Nakata,
    M.Nakanishi, M.Sanada, S.Nagayama, M.Matsui.
    Relationship of systemic inflammation and cellular immunity with
    advancement of cognitive decline in patients with Alzheimer's disease.
    Clin Exp Neuroimmunol 9, 2018 (doi : 10.1111 / cen3. 12454)
  • M. Fujita-Nakata, R. Tomioka, K. Tanaka, M. Nakanishi, S. Nagayama, R. Takahashi, T. Machiya, T. Hamada, M. Matsui.
    Intractable cough as characteristic symptom of neuromyelitis optica and neuromyelitis optica spectrum disoder. Mult Scler 22:576-577, 2016.
  • M. Matsui, Y. Shimizu, H. Doi, R. Tomioka, I. Nakashima, M. Niino, J-i. Kira.
    Japanese guidelines for fingolimod in multiple sclerosis: Putting into practice. Clin Exp Neuroimmunol 5: 34-48, 2014.
  • M. Kaito, S-i. Araya, Y. Gondo, M. Fujita, N. Minato, M. Nakanishi, M. Matsui.
    Relevance of distinct monocyte subsets to clinical course of ischemic stroke patients. PLOS one 8: e69409, 2013.
  • N. Hashiba, S. Nagayama, S-i. Araya, H. Inada, Y. Sonobe, A. Suzumura, M. Matsui.
    Phenytoin at optimum doses ameliorates experimental autoimmune encephalomyelitis via modulation of immunoregulatory cells.
    J Neuroimmunol 233: 112-119, 2011.

External Research Funding

  • From the Ministry of Health, labor and Welfare of Japan. A Health and Labour Sciences Research Grant on Rare and Intractable Diseases. Evidence-based Early Diagnosis and Treatment Strategies for Neuroimmunological Diseases;since 2014-2016.(M.Matsui)
  • From the Ministry of Education, Culture, Sports, Science and Technology of Japan. Grant-in-Aid for Scientific Research. Study of allergic reaction using anti-galectin 9 antibody in an animal model of human disease multiple sclerosis. 2005-2006. (M. Matsui)
  • From the Institute for Virus Research Kyoto University.Grant for Collaborative Research of Virus Infection and Biosciences. Study of the effect of immunoregulation induced by modulation of TBP-2 expression in experimental autoimmune encephalomyelitis. 2011. (S. Nagayama)
  • From the Ministry of Health,Labour and Welfare of Japan. Validation of Evidense – based Diagnosis and Guidelines,and lmpact on QOL in Patients with Neuroimmunological Diseases; since 2017. (M.Matsui)